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    M Brothers at Mayo

    American
    Open now4AM - 11:45PM
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    Thanksgiving 2026 Packages

    • Signature Thanksgiving Package 2026 (Dinner for 4-5)

      Dinner for 4-5 MAINS: (CHOOSE 1) - Thyme & Citrus Roasted Turkey - Honey Glazed Ham SIDES: (CHOOSE 3) - Cornbread Stuffing - Green Bean Almondine - Rosemary & Sage Roasted Sweet Potatoes - Baked Truffle Mac & Cheese (+$10) INCLUDES: - Cranberry Sauce - Gravy - Dulce de Leche Pumpkin Pie with Pecan Brown Butter Streusel Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $199.00
    • Grand Thanksgiving Package 2026 (Dinner for 6-8)

      Dinner for 6-8 MAINS: (CHOOSE 2 - MIX & MATCH OR DOUBLE UP ON YOUR FAVORITE!) - Thyme & Citrus Roasted Turkey - Honey Glazed Ham SIDES: (CHOOSE 4) - Cornbread Stuffing - Green Bean Almondine - Rosemary & Sage Roasted Sweet Potatoes - Baked Truffle Mac & Cheese (+$10) INCLUDES: - House Yeast Rolls with Maldon Sea Salt Butter (12ct) - Cranberry Sauce - Gravy - Dulce de Leche Pumpkin Pie with Pecan Brown Butter Streusel Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $265.00

    Thanksgiving 2026 a la Carte

    • a la Carte Honey Glazed Ham

      Sliced ham finished with a sweet, honey glaze that caramelizes beautifully for a savory-sweet holiday centerpiece. Serves 4–5. Approximately 3 lbs. Gluten-free. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $50.00
    • a la Carte Thyme & Citrus Roasted Turkey

      Tender turkey roasted and sliced with fragrant thyme and bright citrus, offering a beautifully seasoned blend of juicy breast, rich thigh, and flavorful leg meat. Serves 4–5. Approximately 3 lbs. Gluten-free. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $55.00
    • al la Carte Baked Truffle Mac n’ Cheese

      Creamy, indulgent macaroni and cheese baked until bubbling and golden, with a rich, earthy touch of truffle. Serves 4–5. Gluten-free option not available. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $40.00
    • al la Carte Cornbread Stuffing

      Savory cornbread stuffing baked until golden and tender, with comforting herbs and rich, holiday flavors in every bite. Serves 4–5. Gluten-free option not available. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $30.00
    • al la Carte Green Bean Almondine

      Crisp-tender green beans tossed with toasted almonds for a bright, buttery side with just the right amount of crunch. Serves 4–5. Gluten-free. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $30.00
    • a la Carte House Yeast Rolls w/ Maldon Salt Whipped Butter

      Warm, pillowy house-made yeast rolls served with creamy whipped butter finished with Maldon salt (12ct). Gluten-free option not available. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $20.00
    • al la Carte Rosemary & Sage Roasted Sweet Potatoes

      Sweet potatoes roasted until caramelized and tender, fragrant with rosemary and sage for a perfectly savory-sweet holiday side. Serves 4–5. Gluten-free. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $30.00
    • al la Carte Whipped Yukon Gold Potatoes

      Creamy Yukon Gold potatoes whipped until smooth and velvety, with a rich, buttery finish that makes them a classic holiday favorite. Serves 4–5. Gluten-free. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $30.00
    • al la Carte Cranberry Sauce

      Bright, tart cranberries simmered into a vibrant sauce with just the right touch of sweetness. A classic complement to every Thanksgiving plate. Serves 4–5. Gluten-free. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $12.00
    • al la Carte Roasted Turkey Pan Gravy

      Rich, savory pan gravy made from roasted turkey drippings, perfect for spooning over turkey, potatoes and stuffing. Serves 4–5. Gluten-free option available. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $12.00
    • a la Carte Dulce de Leche Pumpkin Pie w/ Pecan Brown Butter Streusel

      Silky pumpkin pie layered with luscious dulce de leche and topped with a buttery pecan brown butter streusel for a rich, indulgent finish. Whole pie, 9 inches. Gluten-free option available. Important Pickup Notice: Our system cannot schedule orders for set future dates. Please select your desired pickup date and time for each item ordered. This selection is your confirmed pickup time, and your order will be ready accordingly. Disregard any confirmation stating “ready in 15–20 minutes.”
      $30.00

    All hours
    Sunday4:00 am - 11:45 pm
    Monday4:00 am - 11:45 pm
    Tuesday4:00 am - 11:45 pm
    Wednesday4:00 am - 11:45 pm
    Thursday4:00 am - 11:45 pm
    Friday4:00 am - 11:45 pm
    Saturday4:00 am - 11:45 pm
    Restaurant info

    M Brothers at Mayo Clinic is a full-service dining experience located in the heart of Jacksonville’s Mayo Clinic, welcoming both visitors and the public. Inspired by the legacy of excellence set forth by The Mayo Brothers, William and Charles Mayo, and continued by the culinary craftsmanship of Matthew and David Medure, M Brothers embodies a passion for quality, innovation, and exceptional hospitality. With a dedication to high culinary standards, we bring thoughtfully curated dishes, impeccable presentation, and a stylish yet comfortable ambiance to every guest. Whether you're looking for an elegant dinner, a casual lunch, or a relaxing evening in our lounge, M Brothers is the perfect destination for an elevated dining experience.

    Location

    4500 San Pablo Rd S, Jacksonville, FL 32224

    Directions

    Toast logo

    333 Summer Street
    Boston, MA 02210

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